El losartán pertenece al grupo de los inhibidores de los receptores de angiotensina II, fármacos muy utilizados en el momento actual para el tratamiento de la. Queratodermia palmoplantar epidermolítica asociada a pelo lanoso, syndrome de Ehlers Danlos y miocardiopatía dilatada. Gaceta Dermatológica Ecuatoriana. Dermatol. peru. ; 13 (2): – HIPERQUERATOSIS PALMOPLANTAR Y ENFERMEDAD PERIODONTAL: SÍNDROME DE PAPILLON – LEFÉVRE – A.

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Summary and related texts. It is also expressed at high levels in various immune cells including polymorphonuclear leukocytes, macrophages and their precursors 12, Diagnostic methods Diagnosis is clinical but can be confirmed palmoplxntar detection of the disease-causing mutation.

Multiple periodontal abscesses, pathologic migration and moderate to intense mobility affecting all the teeth were seen. It gives preference to those studies related to fungi and their pathogenic action on human beings and animals, but any scientific study on Mycology will be considered.

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Health care resources for this disease Expert centres Diagnostic tests 6 Patient organisations 25 Orphan drug s 0. Laboratory tests included complete blood count CBCalkaline phosphatase and blood biochemistry. Facial Majocchi’s granuloma caused by Trichophyton tonsurans in an immunocompetent patient.

The patient’s tongue was bright and smooth with no papillae and white plaques on the oral mucosa consistent with the diagnosis of oral candidiasis. The soles of the feet are severely affected and hyperkeratosis is preceded by erythema. Adults infections by T.

Orphanet: Hiperqueratosis palmoplantar periodontopat a onicogriposis

Additional information Further information on this disease Classification s 5 Gene s 1 Other website s 3. Because the aetiology and pathogenesis of PLS periodontitis is directly related to high levels of A actinomycetemcomitans, the administration of an antibiotic that acts specifically on this pathogen has been claimed to be important for a successful treatment plan palmopalntar, SNIP measures contextual citation impact by wighting citations based palmoplamtar the total number of citations in a subject field.

HMS is rare with less than cases reported in the literature so far. Bacterial studies of plaque at the site of the lesion in PLS showed a flora similar to that of periodontitis and was composed basically of virulent Gram-negative anaerobic pathogens such as Porphyromonas gingivalis, Prevotella intermedia and Actinomyces actinomycetemcomitans 5, 9. Hiperqueratosus uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact.


Hiperqueratosis palmoplantar asociada a losartán | Actas Dermo-Sifiliográficas (English Edition)

Only hiperquerwtosis seeking to improve the quality and accuracy of information on the Orphanet website are accepted. Abstract Palmoplantar keratodermas represent a heterogenic group of diseases characterized by the abnormal skin thickening of the palms and soles. Continuing navigation will be considered as acceptance of this use. The patient also had cervical, axillary and inguinal lymphadenomegaly, and we observed areas of diffuse non-scarring and circumscribed alopecia on the scalp Fig.

Patients may benefit from extraction of the primary teeth combined with oral antibiotics and professional tooth hipeqrueratosis. September Pages It palmoplntar possible that our patient had already had a severe dermatophytosis in the past, but it was not possible to determine if he was already HIV positive at that time.

Even so she had not sought treatment until age 8 years. Mutation analysis of the cathepsin C gene in Indian families with Papillon-Lefevre syndrome.

Heavy deposits of supragingival and subgingival plaque and calculus indicated inadequate oral hygiene habits. We requested anti-HIV reactive and anti-HTLV non-reactive serology; the hemogram revealed leukopenia while other laboratory tests were normal.

Successful periodontal maintenance of a case with Papillon-Lefevre syndrome: Haim-Munk syndrome HMS is characterized by palmoplantar hyperkeratosis, severe early-onset periodontitis, onychogryposis, pes planus, arachnodactyly and acroosteolysis. Another management would include continuous and combined use of mechanical control of plaque and systemic hiperrqueratosis with specific antibiotics which could change the course of disease 9, J Am Acad Dermatol ; To improve our services and products, we use “cookies” own or third parties authorized to show advertising related to client preferences oalmoplantar the analyses of navigation customer behavior.

Localization of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.


The differential diagnosis of PLS includes conditions such as hypophosphatasia, histiocytosis X, Haim Munk syndrome, Melada disease and Prepubertal periodontitis. Key words palmoplantar keratoderma, differential diagnosis, palmoplantar keratoderma, connexins, chronic regional endemic hydroarsenicis. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years.

Other authors presented different protocols, such as extraction of deciduous teeth, followed by antibiotic therapy during and after permanent ihperqueratosis eruption. This enzyme is a lysosomal cysteine proteinase that plays an important role in intracellular degradation of proteins and also processes and activates several leukocyte and mast cell granules, serine proteinases, critical to immune and inflammatory responses Pemphigus Vegetans in the Inguinal Folds.

Use of low dose acitretin therapy in the present case showed satisfactory reduction in hyperkeratotic lesions on the palms and soles. The hands are also affected but to a lesser degree 2, 5. Body and facial keratosis pilaris are additional features which appear in the following years.

However, there is little evidence of antibiotic therapy having an effect on the prognosis of the dentition hiperqyeratosis no controlled trials have been carried out.

We review the case of palmoplantar lesions that developed in a patient taking losartan and the subsequent remission after treatment withdrawal.

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The excellent response to the treatment, with a complete regression of the cutaneous lesions Fig. You can change the settings or obtain more information by clicking here. Destructive arthritis of the wrist and shoulder joints has been reported in isolated cases. Ten years before, similar symptoms were treated in another palmkplantar service with clinical improvement. Occasionally, nodules, plaques or abscesses may appear in immunocompromised patients.